Charlotte is the most populous city in the U.S. state of North Carolina. Located in the Piedmont region, it is the county seat of Mecklenburg County. The population was 874,579 as of the 2020 census, making it the 16th-most populous city in the U.S., the second-largest city in the Southeast behind Jacksonville, Florida, and seventh-largest city in the Southern United States. The city is the cultural, economic, and transportation center of the Charlotte metropolitan area, whose population ranks 23rd in the U.S., and had a population of 2,660,329, in 2020. The Charlotte metropolitan area is part of a sixteen-county market region or combined statistical area with a 2020 census-estimated population of 2,846,550.