Minneapolis is the most populous city in the US state of Minnesota and the seat of Hennepin County. With an estimated population of 429,606 as of 2019, it is the 46th most populous city in the US. Seven counties encompassing Minneapolis and its neighbor Saint Paul are known as the Twin Cities. In 2019, those counties are among sixteen making up the Minneapolis–St. Paul–Bloomington MN–WI metropolitan area of 3.6 million, and twenty-two making up the combined statistical area of 4.0 million.